We have had similar issues we are using the Intell X710. Every few weeks since upgrading to ESXi 6.5 the networking on one of our hosts has been locking up. We stumbled across the below article which described the issue well and also mentions disabling the i40en driver.
https://communities.vmware.com/thread/552470 Install ESXi 6.5 on R730 with Intel X710 |VMware Communities
Note we were on firmware version 1.3.1, did this issue get resolved with an upgrade to 1.4.3 NIC Driver for Intel Ethernet Controllers X710?
Looking in some forums some people ordered new nics to get around the issue.
Driver version 1.4.3 does fix the issue and if you still experience problem after upgrading to 1.4.3 , please let us know. Thank you.
/community/tech/wired/blog/2018/05/23/malicious-driver-detection-mdd-event-resolved Malicious Driver Detection (MDD) Event – Resolved
The Malicious Driver Detection issue that we are aware of is addressed in the 1.7.1 i40en driver release for ESXi 6.7 available for download here: https://my.vmware.com/web/vmware/details%3FdownloadGroup%3DDT-ESXI67-INTEL-I40EN-171%26productId%3D7... Link to Download
Note: Drivers that address the MDD issue for ESXi 6.0 & ESXi 6.5 will be available in a future release.
For more information please see the blog post: /community/tech/wired/blog/2018/05/23/malicious-driver-detection-mdd-event-resolved Malicious Driver Detection (MDD) Event – Resolved