OK, to answer my own question. As of 12.1SP1, the original DE2 is supported but the DE2-115 is not. I could not find support for any Cyclone IV E devices. This is a real shame. We upgraded 30 boards in our labs from the DE2 to the DE2-115 and now we'll have to go back!Anybody from Altera here? Any chance we might see support in an upcoming release?