The reason is that simulation does not support I2C i/f. Go to the "IP" tab, scroll down and untick "Include I2C master/slave" then you will see the simulation box is visible.
We do not receive any response from you to the previous question/reply/answer that I have provided. This thread will be transitioned to community support. If you have a new question, feel free to open a new thread to get the support from Intel experts. Otherwise, the community users will continue to help you on this thread. Thank you.