Hello @Shifali15 ,
If EN pin left floating this will cause the part to be off, but there is a chance that the part could startup under that condition if there is any voltage charge (due to any electrostatics) higher than 0.4V on that pin.
Hi @Shifali15 ,
So sorry for late response, I have reviewed your layout and looks okay.
I would recommend inserting 10Ohm between AVIN and PVIN.
Also please help to confirm if Enable is connected to AVIN or you are using external signal to trigger the Enable pin.