Thanks for your interest in our products. Just for you to know, this thread has been moved to the sub-forum.
Intel® Optane™ Memory can be paired with any SATA based drive as long as the system meets the requirements. The drive capacity is not part of these requirements and a 4TB SATA HDD should work fine.
You can learn more about the product requirements and features here:
- https://www.intel.com/content/www/us/en/support/articles/000023994/memory-and-storage/intel-optane-m... Overview and Requirements for Intel® Optane™ Memory
- https://www.intel.com/content/www/us/en/support/articles/000024018/memory-and-storage/intel-optane-m... Frequently Asked Questions for Intel® Optane™ Memory
Please let us know if there's anything else we can do for you.