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Will amd hd5450 run with i3 10100F?
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Yes, this graphics card should work with this processor and Windows 10. Information on the Windows 10 support for AMD graphics cards can be found here: https://www.amd.com/en/support/kb/faq/gpu-615.
I would add that this is a pretty old graphics card and likely pokey in its performance. Here is specs for this card family: https://www.techpowerup.com/gpu-specs/radeon-hd-5450.c503.
Hope this helps,
...S

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