Predication is used to make a branch conditional. Maybe you mean the branch hints, which can be used to initialize branch prediction to "taken" or "not taken." The first time the predication doesn't match the hint, for example on loop exit, there would always be a mis-predict. Later on, if the predication matches a pattern stored in branch history, it may be possible to "predict," if the pattern continues.
Normally, the hint is set by the compiler, by rules such as backward jump taken, forward conditional jump not taken, and, we hope, loop exit not taken. If the compiler is instructed to use a profiling history, it would set the hints accordingly.
