I don't think you can infer anything about the cause of the hotspot from the samples and instruction to which they were attributed. There are two reasons:
- "Event skid" causes the event to be attributed to an instruction that follows the actual instruction that caused the event. In the case of time-based sampling, I suspect there is "skid" but for a different reason than EBS.
- TBS simply tells you where there is significant activity, not why. You need to start using EBS to try to determine why. You might start by using the Tuning Assistant in the Sampling Wizard and selecting the Primary Performance Events group (can't remember the exact name, but "Primary" is in there somewhere).
Right now, with the data you have, you simply know that this code section is taking a significant amount of time to execute, relative to the rest of the code.