As I understand it, you observe some issue with the DSP builder installation. To ensure we are on the same page, just would like to check with you:
1. What are the Quartus version and Matlab version that you are using?
2. Are you referring to Standard or Advanced blockset?
3. Mind share with me also the step of installation that you are using? Generally it is recommended to the compatible Matlab installed followed by the DSP builder.