As I understand it, you have some inquiries related to the DSP builder version compatibility. For your information, the latest MATLAB version supported by DSP Builder 19.1 is R2018b only. You might need to use R2018b with DSP Builder 19.1 to ensure compatibility. Sorry for the inconvenience.
You may refer to the following link for the supported versions:
Please let me know if there is any concern. Thank you.