Is there the only way to reload the QSF is exit Quartus and then open it? Could the QSF be reloaded from Quartus?
To generate a .qsf file from the Intel Quartus Prime software, click Assignments > Export Assignments & then Open *.qsf from 'File'->'Open' Menu. here you can edit & save it
Please refer the link below for more details,
For more complete information about compiler optimizations, see our Optimization Notice.